Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito

Molecules

Jae-Woo Jung³  Nam-In Baek³  Jeon Hwang-Bo¹  Seung-Su Lee³  Ji-Hae Park³  Kyeong-Hwa Seo³  Jung-Hwa Kwon³  Eun-Ji Oh³  Dae-Young Lee²  In-Sik Chung¹  Myun-Ho Bang³ 

[1] Graduate School of Biotechnology and Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Korea;Department of Herbal Crop Research, National Institute of Horicultural and Herbal Science, RDA, Eumseong 369-873, Korea;Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea;

关键词: Adonis multiflora;    adonioside A;    adonioside B;    cardenolide;    cytotoxic activity;   

DOI  :  10.3390/molecules201119722

来源: mdpi

【 摘 要 】

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.