Entropy | |
Theoretical Search for RNA Folding Nuclei | |
Leonid B. Pereyaslavets2  Oxana V. Galzitskaya1  | |
[1]Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia | |
[2] E-Mail | |
关键词: RNA domain; phi value; RNA folding; mutant; pseudoknot; hairpin; stability; | |
DOI : 10.3390/e17117827 | |
来源: mdpi | |
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【 摘 要 】
The functions of RNA molecules are defined by their spatial structure, whose folding is regulated by numerous factors making RNA very similar to proteins. Prediction of RNA folding nuclei gives the possibility to take a fresh look at the problems of the multiple folding pathways of RNA molecules and RNA stability. The algorithm previously developed for prediction of protein folding nuclei has been successfully applied to ~150 various RNA structures: hairpins, tRNAs, structures with pseudoknots, and the large structured P4-P6 domain of the
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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