Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi

International Journal of Molecular Sciences

Wan-Fei Li¹  Juan Wang²  Jing-Jie Zhang¹  Xun Song²  Chuen-Fai Ku²  Juan Zou¹  Ji-Xin Li¹  Li-Jun Rong³  Lu-Tai Pan¹  Hong-Jie Zhang² 

[1] Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China;School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China;Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA;

关键词: Pteris henryi;    ent-kaurane diterpene;    henrin A;    bioactivity evaluation;    anti-HIV activity;   

DOI  :  10.3390/ijms161126071

来源: mdpi

【 摘 要 】

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC₅₀ value of 9.1 µM (SI = 12.2).

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.