Dermal Contributions to Human Interfollicular Epidermal Architecture and Self-Renewal

International Journal of Molecular Sciences

Kynan T. Lawlor¹  Pritinder Kaur² 

[1] Hudson Institute of Medical Research, Clayton, VIC 3168, Australia

关键词: keratinocyte;    epidermis;    self-renewal;    dermis;    stem cell;    microenvironment;    vasculature;    pericyte;    endothelial;    fibroblast;   

DOI  :  10.3390/ijms161226078

来源: mdpi

【 摘 要 】

The human interfollicular epidermis is renewed throughout life by populations of proliferating basal keratinocytes. Though interfollicular keratinocyte stem cells have been identified, it is not known how self-renewal in this compartment is spatially organized. At the epidermal-dermal junction, keratinocytes sit atop a heterogeneous mix of dermal cells that may regulate keratinocyte self-renewal by influencing local tissue architecture and signalling microenvironments. Focusing on the rete ridges and complementary dermal papillae in human skin, we review the identity and organisation of abundant dermal cells types and present evidence for interactions between the dermal microenvironment and the interfollicular keratinocytes.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.