International Journal of Molecular Sciences | |
Molecular Evolution of the TET Gene Family in Mammals | |
Hiromichi Akahori2  Stéphane Guindon1  Sumio Yoshizaki2  Yoshinori Muto2  | |
[1]Department of Statistics, the University of Auckland, Auckland 1010, New Zealand | |
[2]United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan | |
关键词: molecular evolution; ten-eleven translocation (TET) protein; positive selection; mammal; | |
DOI : 10.3390/ijms161226110 | |
来源: mdpi | |
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【 摘 要 】
Ten-eleven translocation (TET) proteins, a family of Fe2+- and 2-oxoglutarate-dependent dioxygenases, are involved in DNA demethylation. They also help regulate various cellular functions. Three TET paralogs have been identified (TET1, TET2, and TET3) in humans. This study focuses on the evolution of mammalian TET genes. Distinct patterns in TET1 and TET2
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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