Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

Viruses

Olivier Reynard¹  Xuan-Nhi Nguyen²  Nathalie Alazard-Dany¹  Véronique Barateau²  Andrea Cimarelli²  Viktor E. Volchkov¹ 

[1]Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, France

[2]Host Pathogen interaction during lentiviral infection, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, France

关键词: Ebola;    Marburg;    Filovirus;    polymerase;    antiviral;    inhibitors;   

DOI  :  10.3390/v7122934

来源: mdpi

【 摘 要 】

The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.