Internal Fat and Cardiometabolic Risk Factors Following a Meal-Replacement Regimen vs. Comprehensive Lifestyle Changes in Obese Subjects

Nutrients

Daniel König²  Denise Zdzieblik²  Peter Deibert¹  Aloys Berg²  Albert Gollhofer² 

[1] Department of Exercise and Sports Medicine, Centre for Internal Medicine, University Hospital Freiburg, Hugstetterstr. 175, 79106 Freiburg, Germany;Department for Nutrition, Institute for Sports and Sports Science, University of Freiburg, Schwarzwaldstr. 175, 79117 Freiburg, Germany;

关键词: meal replacement;    visceral fat;    metabolic syndrome;    lifestyle intervention;   

DOI  :  10.3390/nu7125500

来源: mdpi

【 摘 要 】

The aim of the present study was to investigate the effect of a meal-replacement regimen vs. comprehensive lifestyle changes in overweight or obese subjects on intra-abdominal fat stores (Magnetic Resonance Imaging (MRI) measurements) and cardiometabolic risk factors. Forty-two obese men (n = 18) and women (n = 24) (age 49 ± 8 years; weight 96.3 ± 12.1 kg; BMI 32.7 ± 2.3 kg/m²) were selected for this randomized parallel-group design investigation. Subjects in the lifestyle group (LS-G; n = 22) received dietary counselling sessions and instructions how to increase physical activity. In the meal replacement group (MR-G; n = 20) meals were replaced by a low-calorie drink high in soy protein. After six months, subjects in the LS-G lost 8.88 ± 6.24 kg and subjects in the MR-G lost 7.1 ± 2.33 kg; p < 0.01 for changes within groups; no significant differences were found between the groups. Lean body mass remained constant in both intervention groups. MRI analyses showed that internal fat was significantly reduced in both groups to a comparable amount; the higher fat loss in the LS-G in the abdominal area was due to a higher reduction in subcutaneous fat. Both interventions significantly reduced components of the cardiometabolic risk profile and leptin levels. The decrease in the adipokines fetuin A and resistin was more pronounced in the MR-G. In conclusion, both interventions significantly reduced body weight, total fat mass and internal abdominal fat while preserving lean body mass. The reduction in the adipokines fetuin A and resistin was more pronounced in the meal replacement group suggesting an additional effect of soy protein components.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.