Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study

Nutrients

Frances A. Tylavsky³  Mehmet Kocak³  Laura E. Murphy¹  J. Carolyn Graff⁴  Frederick B. Palmer⁴  Eszter Völgyi³  Alicia M. Diaz-Thomas² 

[1] Department of Psychiatry, University of Tennessee Health Science Center, 711 Jefferson Avenue, Memphis, TN 38163, USA;Division of Pediatric Endocrinology, Department of Pediatrics, University of Tennessee Health Science Center, 50 N. Dunlap Street, Memphis, TN 38103-2800, USA;Department of Preventive Medicine, University of Tennessee Health Science Center, 66 N. Pauline Street, Memphis, TN 38163-2181, USA;Boling Center for Developmental Disabilities, University of Tennessee Health Science Center, 711 Jefferson Avenue, Memphis, TN 38163-2167, USA;

关键词: vitamin D;    language development;    cognitive development;    prenatal nutrition;    CANDLE study;    gestation;   

DOI  :  10.3390/nu7125499

来源: mdpi

【 摘 要 】

Emerging data suggest that vitamin D status during childhood and adolescence can affect neurocognitive development. The purpose of this study was to investigate whether gestational 25(OH)D status is associated with early childhood cognitive and receptive language development. The Conditions Affecting Neurocognitive Development and Learning in Early Childhood Study (CANDLE) study enrolled 1503 mother-child dyads during the second trimester of healthy singleton pregnancies from Shelby County TN. Among 1020 participants of the total CANDLE cohort for whom 25(OH)D levels were available, mean gestational 25(OH)D level during the second trimester was 22.3 ng/mL (range 5.9–68.4), with 41.7% of values <20 ng/dL. Cognitive and language scaled scores increased in a stair-step manner as gestational 25(OH)D levels in the second trimester rose from <20 ng/dL, through 20–29.99 ng/dL, to ≥30 ng/dL. When controlling for socioeconomic status, race, use of tobacco products, gestational age of the child at birth, and age at the 2-year assessment, the gestational 25(OH)D was positively related to receptive language development (p < 0.017), but not cognitive or expressive language.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.