Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites

Antioxidants

Ambar K. Choudhury²  Suganya Raja²  Sanjata Mahapatra²  Kalyanam Nagabhushanam¹  Muhammed Majeed² 

[1] Sabinsa Corporation-East Windsor, NJ 08520, USA;Sami Labs Limited, Bangalore 560058, India; E-Mails:

关键词: curcumin monoglucuronide;    curcumin diglucuronide;    Synthesis;    Anti-oxidant;    DPPH;    ORAC;   

DOI  :  10.3390/antiox4040750

来源: mdpi

【 摘 要 】

Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant activity (DPPH method) and the anti-oxidant capacity of curcumin diglucuronide is highly attenuated compared to the anti-oxidant activity of curcumin.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.