Polymers | |
Synthesis of ABA Tri-Block Co-Polymer Magnetopolymersomes via Electroporation for Potential Medical Application | |
Jennifer Bain2  Matthew E. Berry1  Catherine E. Dirks1  Sarah S. Staniland1  | |
[1] Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK | |
关键词: ABA tri-block co-polymer; polymersomes; magnetic nanoparticles; electroporation; biomedicine; bioinspired; | |
DOI : 10.3390/polym7121529 | |
来源: mdpi | |
【 摘 要 】
The ABA tri-block copolymer poly(2-methyloxazoline)–poly(dimethylsiloxane)–poly(2-methyloxazoline) (PMOXA–PDMS–PMOXA) is known for its capacity to mimic a bilayer membrane in that it is able to form vesicular polymersome structures. For this reason, it is the subject of extensive research and enables the development of more robust, adaptable and biocompatible alternatives to natural liposomes for biomedical applications. However, the poor solubility of this polymer renders published methods for forming vesicles unreproducible, hindering research and development of these polymersomes. Here we present an adapted, simpler method for the production of PMOXA–PDMS–PMOXA polymersomes of a narrow polydispersity (45 ± 5.8 nm), via slow addition of aqueous solution to a new solvent/polymer mixture. We then magnetically functionalise these polymersomes to form magnetopolymersomes via
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190002397ZK.pdf | 3898KB | download |