Molecules | |
Synthesis and Biological Evaluation of Norcantharidin Derivatives Possessing an Aromatic Amine Moiety as Antifungal Agents | |
Yang Wang2  Wenbo Sun1  Shunqing Zha2  Huan Wang1  Yalin Zhang1  | |
[1]Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, Northwest A & F University, Yangling 712100, China | |
[2]State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A & F University, Yangling 712100, China | |
关键词: cantharidin; natural product; structural modification; arylamine; fungicidal activity; | |
DOI : 10.3390/molecules201219782 | |
来源: mdpi | |
【 摘 要 】
Based on the structure of naturally produced cantharidin, different arylamine groups were linked to the norcantharidin scaffold to provide thirty six compounds. Their structures were confirmed by melting point, 1H-NMR, 13C-NMR and HRMS-ESI studies. These synthetic compounds were tested as fungistatic agents against eight phytopathogenic fungi using the mycelium growth rate method. Of these thirty six derivatives, seven displayed stronger antifungal activity than did norcantharidin, seven showed higher activity than did cantharidin and three exhibited more significant activity than that of thiabendazole. In particular, 3-(3′-chloro-phenyl)carbamoyl norcantharidate
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190002324ZK.pdf | 895KB | download |