Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines—Flos Lonicerae Japonicae—Fructus Forsythiae Herb Couples as an Example

International Journal of Molecular Sciences

Wei Zhou²  Baochang Cai²  Jinjun Shan¹  Shouchuan Wang¹  Liuqing Di² 

[1] Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China;College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;

关键词: bio-pharmaceutics of TCMs preparations;    active constitutes identification;    evaluation system of bioavailability;    pharmaceutical technologies;    absorption enhancer;   

DOI  :  10.3390/ijms161226132

来源: mdpi

【 摘 要 】

Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind vane in the process of TCM modernization. However, multi-target effects, caused by multiple components in TCMs, hinder not only the construction of the quality evaluation system (bioavailability), but also the application of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review describes the methods in the literature as well as in our thoughts about how to identify the marker components, establish the evaluation system of bioavailability, and improve the bioavailability in TCM preparations. We expect that the current study will be positive and informative.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.