Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins

Molecules

Stella Cascioferro¹  Maria Valeria Raimondi¹  Maria Grazia Cusimano¹  Demetrio Raffa¹  Benedetta Maggio¹  Giuseppe Daidone¹  Domenico Schillaci¹ 

[1] Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche—Sezione di Chimica e Tecnologie Farmaceutiche—Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy;

关键词: pyrrolomycins;    antibiotic resistance;    antibiofilm agents;    pyoluteorin;    pentabromopseudilin;   

DOI  :  10.3390/molecules201219797

来源: mdpi

【 摘 要 】

The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.