From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis

Viruses

Eléonore Pérès¹  Eugénie Bagdassarian¹  Sstien This¹  Julien Villaudy³  Dominique Rigal²  Louis Gazzolo¹  Madeleine Duc Dodon¹ 

[1] Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France;Etablissement français du sang, 69007 Lyon, France;AIMM Therapeutics, Meibergdreef 59, 1105 BA Amsterdam Zuidoost, The Netherlands;

关键词: adult T cell leukemia/lymphoma;    HTLV-1;    humanized mouse models;    oncogenesis;   

DOI  :  10.3390/v7122944

来源: mdpi

【 摘 要 】

The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.