Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma

International Journal of Molecular Sciences

Vincenzo Petrozza²  Antonio Carbone¹  Teresa Bellissimo⁵  Natale Porta²  Giovanni Palleschi¹  Antonio Luigi Pastore¹  Angelina Di Carlo³  Carlo Della Rocca²  Francesco Fazi⁵  William Chi-shing Cho⁴ 

[1]Urology Unit, ICOT, Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy

[2]Pathology Unit, ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy

[3]Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy

[4]

[5]Pathology Unit, ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, ItalyDepartment of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Rome 00161, Italy

关键词: microRNAs;    clear cell renal cell carcinoma;    miR-21-5p and miR-210-3p;   

DOI  :  10.3390/ijms161226160

来源: mdpi

【 摘 要 】

A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.