Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks

Cancers

Nathan R. Jones²  Joseph H. Ashmore³  Sang Y. Lee⁴  John P. Richie¹  Philip Lazarus²  Joshua E. Muscat¹ 

[1] Department of Public Health Sciences, Penn State University College of Medicine, 500 University Drive, CH69, Hershey, PA 17033, USA;Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA;Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA;Department of Neurosurgery, Penn State University College of Medicine, Hershey, PA 17033, USA;

关键词: HFE;    SNP;    iron homeostasis;    oral cancer;    White;    Black;    genotyping;   

DOI  :  10.3390/cancers7040898

来源: mdpi

【 摘 要 】

Background: Polymorphisms in the hemochromatosis (HFE) gene are associated with excessive iron absorption from the diet, and pro-oxidant effects of iron accumulation are thought to be a risk factor for several types of cancer. Methods: The C282Y (rs1800562) and H63D (rs1799945) polymorphisms were genotyped in 301 oral cancer cases and 437 controls and analyzed in relation to oral cancer risk, and serum iron biomarker levels from a subset of 130 subjects. Results: Individuals with the C282Y allele had lower total iron binding capacity (TIBC) (321.2 ± 37.2 µg/dL vs. 397.7 ± 89.0 µg/dL, p = 0.007) and higher percent transferrin saturation (22.0 ± 8.7 vs. 35.6 ± 22.9, p = 0.023) than wild type individuals. Iron and ferritin levels approached significantly higher levels for the C282Y allele (p = 0.0632 and p = 0.0588, respectively). Conclusions: Iron biomarker levels were elevated by the C282Y allele, but neither (rs1800562) nor (rs1799945) was associated with oral cancer risk in blacks and whites.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.