IL-18 and Cutaneous Inflammatory Diseases

International Journal of Molecular Sciences

Ji hyun Lee²  Dae Ho Cho¹  Hyun Jeong Park³ 

[1]Department of Life Science, Sookmyung Women’s University, Seoul 140-742, Korea

[2]Department of Dermatology, Seoul St Mary’s Hospital, College of Medicine, the Catholic University of Korea, Seoul 137-701, Korea

[3]

[4]Department of Dermatology, Yeouido St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Korea

关键词: IL-18;    psoriasis;    atopic dermatitis;    urticaria;    contact dermatitis;    alopecia areata;    drug eruption;    lupus erythematosus;    fibrosis;    graft-versus-host disease;    skin tumor;    skin disease;   

DOI  :  10.3390/ijms161226172

来源: mdpi

【 摘 要 】

Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.