International Journal of Molecular Sciences | |
Protein Arginine Methyltransferase 6 Involved in Germ Cell Viability during Spermatogenesis and Down-Regulated by the Androgen Receptor | |
Manling Luo2  Yuchi Li2  Huan Guo1  Shouren Lin1  Jianbo Chen1  Qian Ma1  Yanli Gu1  Zhimao Jiang1  Yaoting Gui1  | |
[1] Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen 518036, China;Department of Physiology, Shantou University Medical College, Shantou 515041, China; | |
关键词: PRMT6; androgen receptor; testes; migration; apoptosis; | |
DOI : 10.3390/ijms161226186 | |
来源: mdpi | |
【 摘 要 】
Androgens and the androgen receptor (AR) are of great importance to spermatogenesis and male fertility. AR knockout (ARKO) mice display a complete insensitivity to androgens and male infertility; however, the exact molecular mechanism for this effect remains unclear. In this study, we found that the expression levels of
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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