Synthesis and Evaluation of Neuroprotective Selenoflavanones

International Journal of Molecular Sciences

Yong-Sung Choi¹  Dong-Myung Kim²  Yoon-Jung Kim¹  Sai Yang¹  Kyung-Tae Lee³  Jong Hoon Ryu³  Jin-Hyun Jeong¹ 

[1] College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea;Office of Research Affairs, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03720, Korea;College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02453, Korea;

关键词: selenoflavanone;    flavanone;    selenium;    neuroprotect;    antioxidant;    blood-brain barrier (BBB);   

DOI  :  10.3390/ijms161226188

来源: mdpi

【 摘 要 】

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.