Graphene-Based Materials for Stem Cell Applications

Materials

Tae-Hyung Kim²  Taek Lee¹  Waleed A. El-Said¹  Jeong-Woo Choi¹ 

[1]Interdisciplinary Program of Integrated Biotechnology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Korea

[2]School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Korea

关键词: graphene;    graphene oxide;    graphene hybrid materials;    graphene scaffolds;    stem cells;    differentiation;    transplantation;    detection;    biomedical applications;    stem cell engineering;   

DOI  :  10.3390/ma8125481

来源: mdpi

【 摘 要 】

Although graphene and its derivatives have been proven to be suitable for several biomedical applications such as for cancer therapy and biosensing, the use of graphene for stem cell research is a relatively new area that has only recently started to be investigated. For stem cell applications, graphene has been utilized by itself or in combination with other types of materials such as nanoparticles, nanofibers, and polymer scaffolds to take advantage of the several unique properties of graphene, such as the flexibility in size, shape, hydrophilicity, as well as its excellent biocompatibility. In this review, we will highlight a number of previous studies that have investigated the potential of graphene or its derivatives for stem cell applications, with a particular focus on guiding stem cell differentiation into specific lineages (e.g., osteogenesis, neurogenesis, and oligodendrogenesis), promoting stem cell growth, stem cell delivery/transplantation, and effective monitoring of their differentiation. We hope that this review promotes and accelerates the use of graphene-based materials for regenerative therapies, especially for stem cell-based approaches to cure various incurable diseases/disorders such as neurological diseases (e.g., Alzheimer’s disease and Parkinson’s disease), stroke, spinal cord injuries, bone/cartilage defects, and cardiovascular diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.