Biosensors | |
High Content Imaging (HCI) on Miniaturized Three-Dimensional (3D) Cell Cultures | |
Pranav Joshi2  Moo-Yeal Lee1  | |
[1] Department of Chemical & Biomedical Engineering, Cleveland State University, 1960 East 24th Street Cleveland, Ohio, OH 44115-2214, USA; E-Mail | |
关键词: high content imaging; three-dimensional (3D) cell culture; miniaturized cell-based assay; predictive toxicology; | |
DOI : 10.3390/bios5040768 | |
来源: mdpi | |
【 摘 要 】
High content imaging (HCI) is a multiplexed cell staining assay developed for better understanding of complex biological functions and mechanisms of drug action, and it has become an important tool for toxicity and efficacy screening of drug candidates. Conventional HCI assays have been carried out on two-dimensional (2D) cell monolayer cultures, which in turn limit predictability of drug toxicity/efficacy
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190001645ZK.pdf | 572KB | download |