Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers

Sensors

Yangqing Chen¹  Yong Liu¹  Xiaodan Shen¹  Zhimin Chang²  Longhua Tang¹  Wen-Fei Dong²  Mingyu Li¹  Jian-Jun He¹ 

[1] State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China;CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China;

关键词: Microring resonator;    Molecularly imprinted polymers;    Testosterone;   

DOI  :  10.3390/s151229877

来源: mdpi

【 摘 要 】

We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.