International Journal of Molecular Sciences | |
Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing | |
Oana Maria Dragostin1  Sangram Keshari Samal2  Florentina Lupascu1  Andreea Pânzariu1  Peter Dubruel4  Dan Lupascu1  Cristina Tuchilus3  Cornelia Vasile5  Lenuta Profire1  | |
[1]Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania | |
[2]Laboratory of General Biochemistry and Physical Pharmacy, Centre for Nano- and Biophotonics, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium | |
[3]Department of Microbiology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania | |
[4]Polymer Chemistry & Biomaterials Research Group, Ghent University, Krijgslaan 281, S4-Bis, Ghent 9000, Belgium | |
[5]Department of Physical Chemistry of Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania | |
关键词: sulfonamide-chitosan derivatives; film; swelling ratio; biodegradation; antioxidant effects; | |
DOI : 10.3390/ijms161226204 | |
来源: mdpi | |
【 摘 要 】
The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity.
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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