Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles

Applied Sciences

Timo Lessing²  Thomas J. J. Müller¹ 

[1] Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany; E-Mail

关键词: cyclization;    cyclocondensation;    domino reactions;    molecular diversity;    multicomponent reactions;    synthetic methods;   

DOI  :  10.3390/app5041803

来源: mdpi

【 摘 要 】

Sequentially Pd-catalyzed processes are excellent entries to heterocycle synthesis. The broad mechanistic variety combined with often very mild reaction conditions allow the concatenation of elementary organic and organometallic steps to novel sequences in the sense of one-pot domino and multicomponent reactions. Given the numerous opportunities of alkyne coordination and their Pd-mediated transformations, alkynylation and carbometallation play a key role, both for purely organometallic sequences as well as in those processes that are intercepted by cyclocondensation. Pd-catalyzed aminations also find more and more entry into novel heterocycle syntheses based upon this theme.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.