Antioxidants | |
Which Is the Most Significant Cause of Aging? | |
Stefan I. Liochev1  | |
[1] 8 Foxlair Court, Durham, NC 27712, USA; E-Mail | |
关键词: aging; reactive oxygen species; synergy; theory; oxidative stress; free radicals; lifespan; | |
DOI : 10.3390/antiox4040793 | |
来源: mdpi | |
【 摘 要 】
It becomes clearer and clearer that aging is a result of a significant number of causes and it would seem that counteracting one or several of them should not make a significant difference. Taken at face value, this suggests, for example, that free radicals and reactive oxygen species do not play a significant role in aging and that the lifespan of organisms cannot be significantly extended. In this review, I point to the fact that the causes of aging synergize with each other and discuss the implications involved. One implication is that when two or more synergizing causes increase over time, the result of their action increases dramatically; I discuss a simple model demonstrating this. It is reasonable to conclude that this might explain the acceleration of aging and mortality with age. In this regard, the analysis of results and mortality patterns described in studies involving yeasts and
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190001452ZK.pdf | 464KB | download |