Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug

Marine Drugs

Javier A. Garc໚-Vilas¹  Beatriz Martínez-Poveda¹  Ana R. Quesada¹  Miguel Ángel Medina¹ 

[1]Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, Spain

关键词: (+)-aeroplysinin-1;    sponges;    marine drugs;    inflammation;    angiogenesis;    cancer;   

DOI  :  10.3390/md14010001

来源: mdpi

【 摘 要 】

Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.