International Journal of Molecular Sciences | |
The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage | |
Anastasia Velalopoulou1  Sonia Tyagi1  Ralph A. Pietrofesa2  Evguenia Arguiri2  Melpo Christofidou-Solomidou1  Paula Andrade2  | |
[1]Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building, Suite 1016C, Philadelphia, PA 19104, USA | |
关键词: antioxidant; DNA damage; flaxseed; ionizing radiation; lignan; phenolic; radioprotection; SDG; | |
DOI : 10.3390/ijms17010007 | |
来源: mdpi | |
【 摘 要 】
Plant phenolic compounds are common dietary antioxidants that possess antioxidant and anti-inflammatory properties. Flaxseed (FS) has been reported to be radioprotective in murine models of oxidative lung damage. Flaxseed’s protective properties are attributed to its main biphenolic lignan, secoisolariciresinol diglucoside (SDG). SDG is a free radical scavenger, shown in cell free systems to protect DNA from radiation-induced damage. The objective of this study was to investigate the
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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