Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis †

International Journal of Molecular Sciences

Dario Perdicchia¹  Michael S. Christodoulou²  Gaia Fumagalli²  Francesco Calogero²  Cristina Marucci²  Daniele Passarella¹ 

[1] Dipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy

关键词: 2-piperidineethanol;    piperidine alkaloids;    enzymatic resolution;    alkaloid synthesis;   

DOI  :  10.3390/ijms17010017

来源: mdpi

【 摘 要 】

2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a valuable starting material for enantioselective synthesis. Herein, are presented both synthetic and enzymatic methods for the resolution of the racemic 1, as well as an overview of synthesized natural products starting from the enantiopure 1.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.