Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases

International Journal of Molecular Sciences

Hueng-Chuen Fan¹  Ching-Shiang Chi¹  Shin-Nan Cheng¹  Hsiu-Fen Lee⁵  Jeng-Dau Tsai³  Shinn-Zong Lin²  Horng-Jyh Harn⁴ 

[1] Department of Pediatrics, Tung’s Taichung Metroharbor Hospital, Wuchi, Taichung 435, TaiwanGraduate Institute of Immunology, China Medical University, Taichung 404, Taiwan;School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan;;Department of Pathology, China Medical University and Hospital, Taichung 404, TaiwanDepartment of Pediatrics, Taichung Veterans General Hospital, Taichung 407, Taiwan;

关键词: neurodegenerative diseases (NDs);    Parkinson’s disease (PD);    Huntington’s disease (HD);    Alzheimer’s disease (AD);    epigenetics;    Ataxia-telangiectasia-mutated protein kinase (ATM);    neuroinflammation;   

DOI  :  10.3390/ijms17010026

来源: mdpi

【 摘 要 】

Neurodegenerative diseases (NDs) are among the most feared of the disorders that afflict humankind for the lack of specific diagnostic tests and effective treatments. Understanding the molecular, cellular, biochemical changes of NDs may hold therapeutic promise against debilitating central nerve system (CNS) disorders. In the present review, we summarized the clinical presentations and biology backgrounds of NDs, including Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD) and explored the role of molecular mechanisms, including dys-regulation of epigenetic control mechanisms, Ataxia-telangiectasia-mutated protein kinase (ATM), and neuroinflammation in the pathogenesis of NDs. Targeting these mechanisms may hold therapeutic promise against these devastating diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.