Adverse Events in Treating Smear-Positive Tuberculosis Patients in China

International Journal of Environmental Research and Public Health

Tao Zhang¹  Jian Du³  Xiaoyan Yin²  Fuzhong Xue¹  Yanxun Liu¹  Runzi Li¹  Cheng Luo¹  Liang Li³  Xiujun Li¹ 

[1] Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China;National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA 01702-5827, USA;Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;

关键词: adverse events;    tuberculosis epidemiology;    risk factors;    China;   

DOI  :  10.3390/ijerph13010086

来源: mdpi

【 摘 要 】

This study aimed to estimate the adverse events (AE) rate during anti-tuberculosis treatment and to explore AE-related risk factors. New and previously treated smear-positive tuberculosis (TB) cases were enrolled from eight regions in China between April 2009 and October 2010. The AE rate was estimated, and AE risk factors during anti-TB treatment were assessed using Cox proportional models. Among 2091 Chinese subjects with anti-TB treatment, 462 (22.1%, 95% confidence interval (CI), 20.3–23.9) patients developed AE, with liver injury and gastrointestinal reactions constituting the most common AE. Specifically, 9.8% (95% CI, 8.5–11.1) and 6.3% (95% CI, 5.3–7.4) developed liver injuries and gastrointestinal reactions, respectively. We found that AE rate differed by regions, TB knowledge score, symptoms score and smoking status. Liver injuries were associated with age, sex and smoking status; gastrointestinal reactions were associated with education level and symptom score. Improving patients’ knowledge on TB could reduce AE rate.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.