Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Cancers

Evan F. Garner²  Elizabeth A. Beierle¹ 

[1] Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USA

关键词: neuroblastoma;    cancer stem cell;    cancer-associated fibroblasts;    hypoxia;   

DOI  :  10.3390/cancers8010005

来源: mdpi

【 摘 要 】

Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.