Cell Proliferation in Neuroblastoma

Cancers

Laura L. Stafman²  Elizabeth A. Beierle¹ 

[1]Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USA

关键词: neuroblastoma;    MYCN;    kinases;    cell cycle check point inhibitors;   

DOI  :  10.3390/cancers8010013

来源: mdpi

【 摘 要 】

Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a dismal prognosis for children diagnosed with advanced stage or relapsed disease. This review focuses upon factors responsible for cell proliferation in neuroblastoma including transcription factors, kinases, and regulators of the cell cycle. Novel therapeutic strategies directed toward these targets in neuroblastoma are discussed.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.