Individualized Follow-up of Pregnant Women with Asymptomatic Autoimmune Thyroid Disease

International Journal of Molecular Sciences

Dana Stoian³  Stelian Pantea⁴  Madalin Margan³  Bogdan Timar¹  Florin Borcan⁵  Marius Craina³  Mihaela Craciunescu² 

[1] Medical Informatics Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., Timisoara 300041, Romania;Microbiology Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., Timisoara 300041, Romania;Obstetrics Gynecology Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., Timisoara 300041, Romania;;Surgery Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., Timisoara 300041, Romania;Analytical Chemistry Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Sq., Timisoara 300041, Romania

关键词: autoimmune thyroid disease;    subclinical hypothyroidism;    pregnancy;    follow-up;    supplemental therapy;   

DOI  :  10.3390/ijms17010088

来源: mdpi

【 摘 要 】

Maternal hormones are essential for the normal fetal development during pregnancy. Autoimmune thyroid disease is a frequent pathology in our iodine replete region. The aim of this study is to evaluate the occurrence of subclinical hypothyroidism (SCH) in cases with known autoimmune thyroid disease, which were in a euthyroid state prior to pregnancy, and to assess the association between supplemental treatments administered and the outcome of the pregnancy. The study is a prospective interventional controlled study. The two cohorts comprise the interventional group, consisting of 109 pregnant women with known autoimmune asymptomatic thyroid disease, without any levothyroxine (LT4) treatment and an aged-matched control group, with an unknown thyroid disease. After the pregnancy, a monthly evaluation of TSH, FT3, and FT4 was performed. Offspring evaluation was made at birth time. 88.8% of the women developed SCH in the first four weeks of pregnancy. Average LT4 doses increased as the pregnancy progressed. The monthly adjustment was 12.5 or 25 μg. All SCH cases developed in the first trimester of pregnancy. There was no significant difference regarding the gestational week, weight, or length at birth between the interventional group and controls, when TSH values were in the optimal range, during the whole pregnancy. Premature birth was described in one case in the interventional group.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.