Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study

Nutrients

Yongbo Wang⁴  Xiang Gao²  Pardis Pedram²  Mariam Shahidi¹  Jianling Du⁴  Yanqing Yi³  Wayne Gulliver²  Hongwei Zhang² 

[1] Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada;The Discipline of Medicine, Faculty of Medicine, Memorial University, St. John’s, NL A1B 3V6, Canada;Division of Community Health & Humanities, Faculty of Medicine, Memorial University, St. John’s, NL A1B 3V6, Canada;Department of Endocrinology, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning, China;

关键词: dietary selenium intake;    body composition;    confounding factors;    adult population;   

DOI  :  10.3390/nu8010024

来源: mdpi

【 摘 要 】

Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations in serum Se may be associated with obesity. However, there are few studies examining the relationship between dietary Se and obesity, and findings are inconsistent. We aimed to investigate the association between dietary Se intake and a panel of obesity measurements with systematic control of major confounding factors. A total of 3214 subjects participated in the study. Dietary Se intake was determined from the Willett food frequency questionnaire. Body composition was measured using dual-energy X-ray absorptiometry. Obese men and women had the lowest dietary Se intake, being 24% to 31% lower than corresponding normal weight men and women, classified by both BMI and body fat percentage. Moreover, subjects with the highest dietary Se intake had the lowest BMI, waist circumference, and trunk, android, gynoid and total body fat percentages, with a clear dose-dependent inverse relationship observed in both gender groups. Furthermore, significant negative associations discovered between dietary Se intake and obesity measurements were independent of age, total dietary calorie intake, physical activity, smoking, alcohol, medication, and menopausal status. Dietary Se intake alone may account for 9%–27% of the observed variations in body fat percentage. The findings from this study strongly suggest that high dietary Se intake is associated with a beneficial body composition profile.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.