Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

International Journal of Environmental Research and Public Health

Yazmín Hernández-D໚z¹  Carlos Alfonso Tovilla-Zárate³  Isela Juárez-Rojop²  Mar໚ Lilia López-Narvพz⁴  José Francisco Álvarez-Cámara²  Thelma Beatriz González-Castro¹ 

[1] División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México;División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México;División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco 86650, México;Hospital General de Yajalón. Secretaría de Salud, Yajalón, Chiapas 29932, México;

关键词: CAD;    CRP;    TNF-α;    association studies;    Mexican population;   

DOI  :  10.3390/ijerph13010103

来源: mdpi

【 摘 要 】

Background: The C-reactive protein (CRP) and the tumor necrosis factor-alpha (TNF-α) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-α genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-α genes in Mexican individuals. Methods/design: we will perform a case-control study to explore the CRP and TNF-α genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-α gene) in Mexican individuals who present coronary artery disease. Ethics and dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.

【 授权许可】

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.