Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes

Materials

Oliver Bixner¹  Steffen Kurzhals¹  Mudassar Virk¹  Erik Reimhult¹ 

[1] Institute for Biologically Inspired Materials, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, Vienna 1190, Austria;

关键词: superparamagnetic iron oxide nanoparticle;    thermoresponsive polymer;    magneto-polymersome;    magneto-thermal release;    calcein assay;   

DOI  :  10.3390/ma9010029

来源: mdpi

【 摘 要 】

Magnetic polymersomes were prepared by self-assembly of the amphiphilic block copolymer poly(isoprene-b-N-isopropylacrylamide) with monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPION). The specifically designed thermoresponsive block copolymer allowed for efficient incorporation of the hydrophobic nanoparticles in the membrane core and encapsulation of the water soluble dye calcein in the lumen of the vesicles. Magnetic heating of the embedded SPIONs led to increased bilayer permeability through dehydration of the thermoresponsive PNIPAM block. The entrapped calcein could therefore be released in controlled doses solely through exposure to pulses of an alternating magnetic field. This hybrid SPION-polymersome system demonstrates a possible direction for release applications that merges rational polymersome design with addressed external magnetic field-triggered release through embedded nanomaterials.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.