Incobotulinum Toxin-A Improves Post-Surgical and Post-Radiation Pain in Cancer Patients

Toxins

Rezvan Rostami¹  Shivam Om Mittal²  Reza Radmand³  Bahman Jabbari¹ 

[1] Department of Neurology, Yale University School of Medicine, 15 York Street, LCI Building, New Haven, CT 06520, USA;Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH 44106-5040, USA;Department of Surgery, Bridgeport Hospital, 267 Grant Street, Bridgeport, CT 06610, USA;

关键词: incobotulinum toxin A;    onabotulinum toxin A;    radiation;    Patients’ Global Impression of Change;    surgery;    cancer pain;    visual analog scale;   

DOI  :  10.3390/toxins8010022

来源: mdpi

【 摘 要 】

Cancer patients who undergo surgery or radiation can develop persistent focal pain at the site of radiation or surgery. Twelve patients who had surgery or radiation for local cancer and failed at least two analgesic medications for pain control were prospectively enrolled in a research protocol. Patients were injected up to 100 units of incobotulinum toxin A (IncoA) intramuscularly or subcutaneously depending on the type and location of pain (muscle cramp or neuropathic pain). Two patients passed away, one dropped out due to a skin reaction and another patient could not return for the follow up due to his poor general condition. All remaining 8 subjects (Age 31–70, 4 female) demonstrated significant improvement of Visual Analog Scale (VAS) (3 to 9 degrees, average 3.9 degrees) and reported significant satisfaction in Patients’ Global Impression of Change scale (PGIC) (7 out of 8 reported the pain as much improved). Three of the 8 patients reported significant improvement of quality of life.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.