miRNAs Regulation and Its Role as Biomarkers in Endometriosis

International Journal of Molecular Sciences

Josep Marí-Alexandre³  Dolors Sánchez-Izquierdo⁴  Juan Gilabert-Estellés⁵  Moisés Barceló-Molina³  Aitana Braza-Boïls³  Juan Sandoval¹  Nalini Santanam² 

[1]Epigomics Unit, Health Research Institute La Fe, Valencia 46026, Spain

[2]Unit of Hemostasia, Thrombosis, Atherosclerosis and Vascular Biology, Health Research Institute La Fe, Valencia 46026, SpainUnit of Hemostasia, Thrombosis, Atherosclerosis and Vascular Biology, Health Research Institute La Fe, Valencia 46026, Spain

[3]Arrays Unit, Health Research Institute La Fe, Valencia 46026, Spain

[4]Maternal Child Area, General Hospital, Valencia 46014, Spain

关键词: non-coding RNA;    microRNA;    biomarker;    endometriosis;   

DOI  :  10.3390/ijms17010093

来源: mdpi

【 摘 要 】

MicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.