Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition

Materials

Liviu Duta¹  George E. Stan²  Adrian C. Popa³  Marius A. Husanu²  Sorin Moga⁴  Marcela Socol²  Irina Zgura²  Florin Miculescu⁵  Iuliana Urzica¹  Andrei C. Popescu¹  Ion N. Mihailescu¹ 

[1] National Institute for Lasers, Plasma and Radiation Physics, Magurele-Ilfov 077125, Romania;National Institute of Materials Physics, Magurele-Ilfov 077125, Romania;Army Centre for Medical Research, Bucharest 020012, Romania;Research Centre for Advanced Materials, University of Pitesti, Pitesti 110040, Romania;Faculty of Materials Science and Engineering, Politehnica University of Bucharest, Bucharest 060042, Romania;

关键词: titanium nitride;    medical instrument;    pull-out adherence;    cytocompatibility;    pulsed laser deposition;   

DOI  :  10.3390/ma9010038

来源: mdpi

【 摘 要 】

We report a study on the biocompatibility vs. thickness in the case of titanium nitride (TiN) films synthesized on 410 medical grade stainless steel substrates by pulsed laser deposition. The films were grown in a nitrogen atmosphere, and their in vitro cytotoxicity was assessed according to ISO 10993-5 [1]. Extensive physical-chemical analyses have been carried out on the deposited structures with various thicknesses in order to explain the differences in biological behavior: profilometry, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction and surface energy measurements. XPS revealed the presence of titanium oxynitride beside TiN in amounts that vary with the film thickness. The cytocompatibility of films seems to be influenced by their TiN surface content. The thinner films seem to be more suitable for medical applications, due to the combined high values of bonding strength and superior cytocompatibility.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.