International Journal of Molecular Sciences | |
Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity | |
Craig E. Grossman3  Shirron L. Carter3  Julie Czupryna2  Le Wang1  Mary E. Putt1  Theresa M. Busch3  | |
[1] Department of Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; | |
关键词: photodynamic therapy; fluence rate; lung; HPPH; epidermal growth factor receptor; optical imaging; proliferation; thoracic cavity; non-small cell lung carcinoma; | |
DOI : 10.3390/ijms17010101 | |
来源: mdpi | |
【 摘 要 】
Photodynamic therapy (PDT) of the thoracic cavity can be performed in conjunction with surgery to treat cancers of the lung and its pleura. However, illumination of the cavity results in tissue exposure to a broad range of fluence rates. In a murine model of intrathoracic PDT, we studied the efficacy of 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH; Photochlor®)-mediated PDT in reducing the burden of non-small cell lung cancer for treatments performed at different incident fluence rates (75
【 授权许可】
CC BY
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
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