Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin

International Journal of Molecular Sciences

Janina Dose³  Seiichi Matsugo¹  Haruka Yokokawa¹  Yutaro Koshida¹  Shigetoshi Okazaki⁴  Ulrike Seidel³  Manfred Eggersdorfer²  Gerald Rimbach³  Tuba Esatbeyoglu³ 

[1] School of Natural System, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan;DSM Nutritional Products, P.O. Box 2676, 4002 Basel, Switzerland;Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, D-24118 Kiel, Germany;Medical Photonics Research Center, Hamamatsu University School of Medicine, Handamachi 1-20-1, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan;

关键词: astaxanthin;    free radical scavenging;    antioxidant;    electron spin resonance spectroscopy;   

DOI  :  10.3390/ijms17010103

来源: mdpi

【 摘 要 】

Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.