Preparation and Properties of 3D Chitosan Microtubes

Journal of Soft Matter

Natalia O.Gegel¹  Luba S.Vdovykh¹  Tatiana S.Babicheva¹  Anna B.Shipovskaya¹ 

DOI  :  10.1155/2014/863096

学科分类：物理（综合）

来源: Hindawi Publishing Corporation

【 摘 要 】

The preparation of 3D chitosan microtubes from polymer solutions in citric and lactic acids by the wet and dry molding methods is described. The mechanism of formation of the insoluble polymeric layer constructing the walls of these microtubes is characterized. The microtubes obtained from chitosan solutions in citric acid are found to have a fragile porous inner layer. For those obtained from chitosan solutions in lactic acid the morphology, elastic-deformation properties, physicomechanical properties, and biocompatibility were assessed. These samples have smooth outer and inner surfaces with no visible defects and high values of elongation at break. The strength of the microtubes obtained by the dry method is much higher than in the case of the wet one. A high adhesion and high proliferative activity of the epithelial-like MA-104 cellular culture on the surface of our microtubular substrates in modelin vitroexperiments were revealed. Prospects of using chitosan microtubes as vascular prostheses are suggested.

【 授权许可】

Unknown