Treatment ofβ-Thalassemia/Hemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State

Oxidative Medicine and Cellular Longevity

SomdetSrichairatanakool¹  Ruchaneekorn W.Kalpravidh¹  Orn-umaYanpanitch¹  RatiyaCharoensakdi¹  SuneeratHatairaktham¹  NoppadolSiritanaratkul¹  NarumolPanichkul¹  SuthatFucharoen¹ 

DOI  :  10.1155/2015/537954

学科分类：过敏症与临床免疫学

来源: Hindawi Publishing Corporation

【 摘 要 】

Studies on the antioxidant treatment for thalassemia have reported variable outcomes. However, treatment of thalassemia with a combination of hydrophobic and hydrophilic antioxidants and an iron chelator has not been studied. This study investigated the effects of antioxidant cocktails for the treatment ofβ-thalassemia/hemoglobin E (HbE), which is the most common form ofβ-thalassemia in Southeast Asia. Sixty patients were divided into two groups receiving N-acetylcysteine, deferiprone, and either curcuminoids (CUR) or vitamin E (Vit-E), and their hematological parameters, iron load, oxidative stress, and blood coagulation potential were evaluated. Patients were classified as responders if they showed the improvements of the markers of iron load and oxidative stress, otherwise as nonresponders. During treatment, the responders in both groups had significantly decreased iron load, oxidative stress, and coagulation potential and significantly increased antioxidant capacity and hemoglobin concentration. The significantly maximum increase(P<0.01)in hemoglobin concentration was 11% at month 4 in CUR group responders and 10% at month 10 in Vit-E group responders. In conclusion, the two antioxidant cocktails can improve anemia, iron overload, oxidative stress, and hypercoagulable state inβ-thalassemia/HbE.

【 授权许可】

Unknown