Planar Cell Polarity Pathway in Kidney Development and Function

Advances in Nephrology

BrittanyRocque¹  ElenaTorban¹ 

DOI  :  10.1155/2015/764682

学科分类：过敏症与临床免疫学

来源: Hindawi Publishing Corporation

【 摘 要 】

The evolutionarily conserved planar cell polarity (PCP) signaling pathway controls tissue polarity within the plane orthogonal to the apical-basal axis. PCP was originally discovered inDrosophila melanogasterwhere it is required for the establishment of a uniform pattern of cell structures and appendages. In vertebrates, including mammals, the PCP pathway has been adapted to control various morphogenetic processes that are critical for tissue and organ development. These include convergent extension (crucial for neural tube closure and cochlear duct development) and oriented cell division (needed for tubular elongation), ciliary tilting that enables directional fluid flow, and other processes. Recently, strong evidence has emerged to implicate the PCP pathway in vertebrate kidney development. In this review, we will describe the experimental data revealing the role of PCP signaling in nephrogenesis and kidney disease.

【 授权许可】

Unknown