At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

Sarcoma

George T.Calvert¹  Joshua D.Schiffman¹  R. LorRandall¹  StephenLessnick¹  LisaCannon-Albright¹  Kevin B.Jones¹ 

DOI  :  10.1155/2012/152382

学科分类：肿瘤学

来源: Hindawi Publishing Corporation

【 摘 要 】

Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations.This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.

【 授权许可】

Unknown