Symptom Burden, Survival and Palliative Care in Advanced Soft Tissue Sarcoma

Sarcoma

ClareSmith¹  IanJudson¹  JuliaRiley¹  Nicholas J.Gough¹  Joy R.Ross¹ 

DOI  :  10.1155/2011/325189

学科分类：肿瘤学

来源: Hindawi Publishing Corporation

【 摘 要 】

Introduction. The symptom burden and role of palliative care (PC) in patients with advanced soft tissue sarcoma (STS) are not well defined.Methods. This study retrospectively reviewed both symptoms and PC involvement in patients known to an STS referral centre who died in one calendar year.Results. 81 patients met inclusion criteria of which 27% had locally advanced disease and 73% metastases at initial referral. The median number of symptoms was slowly progressive ranging from 2 (range 0–5) before first-line chemotherapy (n=50) to 3 (range 1–6) at the time of best supportive care (BSC) decision (n=48). Pain and dyspnoea were the commonest symptoms. Median overall survival from BSC decision was 3.4 weeks. 88% had PC involvement (either hospital, community, or both) with median time from first PC referral to death of 16 (range 0–110) weeks.Conclusions. Patients with metastatic STS have a significant symptom burden which justifies early PC referral. Pain, including neuropathic pain, is a significant problem. Dyspnoea is common, progressive and appears to be undertreated. Time from BSC decision to death is short, and prospective studies are required to determine whether this is due to overtreatment or very rapid terminal disease progression.

【 授权许可】

Unknown