Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases

International Journal of Proteomics

ShivaKalantari¹  ElmiraGhasemi¹  RahelehMoradpoor¹  AmenehJafari¹  EnsiehKhalkhal¹ 

DOI  :  10.1155/2015/782798

学科分类：生物化学/生物物理

来源: Hindawi Publishing Corporation

【 摘 要 】

Urine has been in the center of attention among scientists of clinical proteomics in the past decade, because it is valuable source of proteins and peptides with a relative stable composition and easy to collect in large and repeated quantities with a noninvasive procedure. In this review, we discuss technical aspects of urinary proteomics in detail, including sample preparation, proteomic technologies, and their advantage and disadvantages. Several recent experiments are presented which applied urinary proteome for biomarker discovery in renal diseases including diabetic nephropathy, immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis, lupus nephritis, membranous nephropathy, and acute kidney injury. In addition, several available databases in urinary proteomics are also briefly introduced.

【 授权许可】

Unknown