PI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical application

American Journal of Cancer Research

Pu Xia¹  Xiao-Yan Xu¹ 

关键词: Cancer stem cells;    PI3K/Akt/mTOR signaling pathway;    self-renew;    tumor initiation;    rapamycin;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self-renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling pathway can be considered as a master regulator for cancer. More and more recent studies have shown the links between PI3K/Akt/mTOR signaling pathway and CSC biology. Herein, we provide a comprehensive review on the role of signaling components upstream and downstream of PI3K/Akt/mTOR signaling in CSC. In addition, we also summarize various classes of small molecule inhibitors of PI3K/Akt/mTOR signaling pathway and their clinical potential in CSC. Overall, the current available data suggest that the PI3K/Akt/mTOR signaling pathway could be a promising target for development of CSC-target drugs.

【 授权许可】

Unknown