NK/T cell lymphoma involving mediastinum: report of a case and review of literature

International Journal of Clinical and Experimental Pathology

Wei-Hua Liao¹  Bao-An Liu¹  Ji-Fang Wen¹  Jian-Hua Zhou¹  Xiang Li¹  Zhong-Liang Hu¹ 

关键词: NK/T cell lymphoma;    mediastinum;    Epstein-Barr virus;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Extranodal natural killer (NK)/T-cell lymphoma is a very aggressive malignant neoplasia with a poor prognosis. Herein we reported a case of NK/T cell lymphoma involving mediastinum. It was a 28-year-old Chinese male patient. The tumor cells were medium-sized, had irregularly folded nuclei, and inconspicuous or small nucleoli with coagulative necrosis. The tumor cells were positive for CD3ε, TIA-1, but negative for CD56. In situ hybridization revealed that tumor cells also expressed Epstein-Barr virus encoded RNA. To our knowledge, this is the first case of NK/T cell lymphoma involving mediastinum.

【 授权许可】

Unknown