miR-183 inhibits invasion of gastric cancer by targeting Ezrin

International Journal of Clinical and Experimental Pathology

Yao Lin¹  Jian-Xian Lin¹  Ping Li¹  Jian-Wei Xie¹  Jia-Bin Wang¹  Qi-Yue Chen¹  Long-Long Cao¹  Chao-Hui Zheng¹  Chang-Ming Huang¹  Jun Lu¹ 

关键词: MicroRNA-183;    gastric cancer (GC);    Ezrin;    metastasis;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

miR-183, a member of an evolutionarily conserved miRNA cluster (miR-96, miR-182, and miR-183), has been demonstrated to act as both a tumor suppressor and oncogene in various type of human cancer. However, the biological role of miR-183 in gastric cancer (GC) still remains unclear. In the present study, miR-183 expression was significantly decreased in gastric cancer tissues compared with its’ adjacent normal tissues, and down-regulation of miR-183 was significantly associated with lymph node metastasis and pathological TNM stage. Furthermore, Erzin, which was reported to be up-regulated in gastric cancer, was identified as an efficient target of miR-183. Overexpression of miR-183 markedly suppressed cells invasion by downregulation of Ezrin expression. However, miR-183 expression didn’t affect cells proliferation and cell cycle distribution of GC. In conclusion, our study demonstrated that miR-183 acts as a tumor suppressor in GC, partially at least via regulation of Ezrin. Therefore, miR-183 may be a potential target for the treatment of gastric cancer.

【 授权许可】

Unknown